Direct amidation of azoles with formamides via metal-free C-H activation in the presence of tert-butyl perbenzoate

A novel and simple method for the direct amidation of azoles with formamides has been developed. The reaction could occur smoothly in the presence of tert-butyl perbenzoate (TBPB) as an oxidant under metal-and base-free conditions. Direct dehydrogenative cross-coupling of formamides and azoles generated the corresponding products in good yields.