SiO2@Fe2O3 core-shell nanoparticles for covalent immobilization and release of sparfloxacin drug

Silica-coated Fe2O3 nanoparticles were synthesized as carriers for the covalent immobilization and release of antimicrobial drug sparfloxacin (SPFX). SPFX-loaded nanoparticles exhibited time-dependent drug release, with no measurable in vitro cytotoxicity, making the drug@nanoparticle conjugates potentially relevant for nanomedicine applications.