☆ 4.7 Article

Enhanced translocation of poly(dt)(45) through an alpha-hemolysin nanopore by binding with antibody

CHEMICAL COMMUNICATIONS (2011)

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期刊

CHEMICAL COMMUNICATIONS
卷 47, 期 20, 页码 5690-5692

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc05787h

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Chemistry, Multidisciplinary

资金

  1. National Natural Science Foundation of China [20875030]
  2. Shuguang Project of Shanghai [07SG36]
  3. Fundamental Research Funds for the Central Universities [WK1013002]
  4. Natural Sciences Engineering and Research Council of Canada
  5. Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

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The translocation time of poly(dT)(45) through an alpha-hemolysin pore was reduced in the presence of a DNA-binding Fab fragment. The Fab acts as a rudder to steer the DNA into the pore.

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