期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 33, 页码 9321-9323出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13213j
关键词
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资金
- European Research Council [ERC 201749]
- Institut Univervsitaire de France (IUF)
We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37 485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.
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