First synthesis of fused-Delta(1)-pyrrolines via intramolecular 1,3-dipolar cycloaddition of ketoimine: A complete diastereoselective approach

Intramolecular formal 1,3-dipolar cycloaddition of ketoimine is developed with PhIO for the first synthesis of fused-Delta(1)-pyrrolines. The scope of the reaction, complete diastereoselectivity and its rationalization by a computational study are reported.