期刊
JOURNAL OF GENERAL VIROLOGY
卷 96, 期 -, 页码 2092-2098出版社
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/vir.0.000176
关键词
-
资金
- NC3Rs grants [G1000033/1, NC/K00042X/1]
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [G1000033/1, NC/K00042X/1] Funding Source: researchfish
Ferrets have become the model animal of choice for influenza pathology and transmission experiments as they are permissive and susceptible to human influenza A viruses. However, inoculation of ferrets with mumps virus (MuV) did not lead to successful infections. We evaluated the use of highly differentiated ferret tracheal epithelium cell cultures, FTE, for predicting the potential of ferrets to support respiratory viral infections. FTE cultures supported productive replication of human influenza A and B viruses but not of MuV, whereas analogous cells generated from human airways supported replication of all three viruses. We propose that in vitro strategies using these cultures might serve as a method of triaging viruses and potentially reducing the use of ferrets in viral studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据