期刊
SEMINARS IN REPRODUCTIVE MEDICINE
卷 18, 期 3, 页码 273-287出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2000-12565
关键词
ovum implantation; trophoblast; signal transduction; growth substances; calcium signaling
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R55HD036764, R03HD036764] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA012057] Funding Source: NIH RePORTER
- NIAAA NIH HHS [AA12057] Funding Source: Medline
- NICHD NIH HHS [HD36764] Funding Source: Medline
The success of blastocyst implantation is dependent on signaling between the embryo and the receptive endometrium. Intercellular signaling molecules, which include hormones, growth factors, and cytokines, have been identified that participate in the maternal-embryonic dialogue. These biologically active molecules may target uterine and/or embryonic tissues in a biochemical cascade that coordinates the two developmental programs during implantation. Two notable uterine products are calcitonin and heparin-binding epidermal growth factor-like growth factor, which are both expressed during the receptive phase of the endometrium in humans and in rodent models. We review data that demonstrate the ability of these molecules to accelerate blastocyst differentiation and delineate the respective intracellular signaling pathways that advance the embryonic developmental program. An understanding of the mediators regulating embryonic development in utero and their biochemical mechanisms of the action may provide insights for improvement of embryo culture in vitro prior to blastocyst transfer.
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