期刊
CHEMICAL COMMUNICATIONS
卷 46, 期 38, 页码 7175-7177出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02634d
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资金
- University Of South Carolina
- TSRI, Scripps Florida
- National Institutes of Health [GM079357]
- NATIONAL CANCER INSTITUTE [R01CA132630] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM079357] Funding Source: NIH RePORTER
Protein Arginine Deiminase (PAD) activity is dysregulated in numerous diseases, e. g., Rheumatoid Arthritis. Herein we describe the development of a fluorescence polarization-Activity Based Protein Profiling (fluopol-ABPP) based high throughput screening assay that can be used to identify PAD-selective inhibitors. Using this assay, streptonigrin was identified as a potent, selective, and irreversible PAD4 inactivator.
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