期刊
ANNUAL REVIEW OF PHYSIOLOGY
卷 62, 期 -, 页码 649-671出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.62.1.649
关键词
angiogenesis; vasculogenesis; endothelial targeting; differentiation
类别
资金
- NATIONAL CANCER INSTITUTE [P30CA068485] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK047078, R01DK038517] Funding Source: NIH RePORTER
- NCI NIH HHS [CA68485] Funding Source: Medline
- NIDDK NIH HHS [R01-DK47078, R01-DK38517] Funding Source: Medline
Regulated assembly of a highly specialized interconnecting network of vascular endothelial and supportive cells is fundamental to embryonic development and organogenesis, as well as to postnatal tissue repair in metazoans. This review advances an endotheliocentric'' model that defines tasks required of endothelial cells and describes molecular controls that regulate steps in activation, assembly, and maturation of new vessels. In addition to the classical assembly mechanisms-angiogenesis and vasculogenesis-endothelial cells are also recruited into vascular structures from the circulatory system in adult animals and from resident mesenchymally derived progenitors during organogenesis of kidney and other organs. Paracrine signaling cascades regulated by hypoxia initiate a sequentially coordinated series of endothelial responses, including matrix degradation, migration, proliferation, and morphogenetic remodeling. Surface receptors on committed endothelial lineage progenitors transduce cues from extracellular-matrix-associated proteins and cell-cell contact to direct migration, matrix attachment, proliferation, targeting and cell-cell assembly, and vessel maturation. Through their capacity to spatially segregate and temporally integrate a diverse range of extracellular signals, endothelial cells determine their migratory paths, cellular partners, and life-or-death responses to local cues.
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