期刊
CLINICAL MICROBIOLOGY REVIEWS
卷 13, 期 1, 页码 16-+出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CMR.13.1.16-34.2000
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资金
- NIAID NIH HHS [AI22159, AI 07421, T32 AI007421, R37 AI022159, R01 AI022159] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007421, R37AI022159, R01AI022159] Funding Source: NIH RePORTER
This article reviews the literature regarding the structure and function of two types of exotoxins expressed by Staphylococcus aureus, pyrogenic toxin superantigens (PTSAgs) and hemolysins. The molecular basis of PTSAg toxicity is presented in the context of two diseases known to be caused by these exotoxins: toxic shock syndrome and staphylococcal food poisoning. The family of staphylococcal PTSAgs presently includes toxic shock syndrome toxin-l (TSST-1) and most of the staphylococcal enterotoxins (SEs) (SEA, SEE, SEC, SED, SEE, SEG, and SEH). As the name implies, the PTSAgs air multifunctional proteins that invariably exhibit lethal activity pyrogenicity, superantigenicity, and the capacity to induce lethal hypersensitivity to endotoxin. Other properties exhibited by one or more staphylococcal PTSAgs include emetic activity (SEs) and penetration across mucosal barriers (TSST-1). A detailed review of the molecular mechanisms underlying the toxicity of the staphylococcal hemolysins is also presented.
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