期刊
CHEMICAL COMMUNICATIONS
卷 46, 期 30, 页码 5506-5508出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc00108b
关键词
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资金
- National Institutes of Health [R01 GM62159]
- Skaggs Institute for Chemical Biology
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062159] Funding Source: NIH RePORTER
A mutant pyrrolysyl-tRNA synthetase/tRNA pair was used to genetically encode allylcarbamoyl methyllysine in bacteria. This amino acid can be converted to methyllysine with a ruthenium catalyst, providing a straightforward approach for site-specifically introducing methyllysine residues into proteins.
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