期刊
CHEMICAL COMMUNICATIONS
卷 46, 期 24, 页码 4330-4332出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc00287a
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资金
- Robert A. Welch Foundation [D-1361]
- NIH [R03DA026960]
- NSFC [20928001]
- NATIONAL INSTITUTE ON DRUG ABUSE [R03DA026960] Funding Source: NIH RePORTER
The asymmetric catalytic Strecker reaction of achiral N-phosphonyl imines with Et2AlCN has been established. Both free amino alcohols and BINOLs have been proven to be effective catalysts to afford excellent enantioselectivities and yields. The N-phosphonyl group can be readily cleaved under mild conditions and enable purification of crude products by simple washing with hexane. The cleaved N,N-dialkyl diamine auxiliary can be recovered quantitatively via n-BuOH extraction. The scope for both N-phosphonyl imines and catalysts was vastly studied for this new catalytic system.
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