期刊
CHEMICAL COMMUNICATIONS
卷 46, 期 44, 页码 8407-8409出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc03738a
关键词
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资金
- Ministry of Education [R-143-000-394-112]
- Agency for Science, Technology and Research (A*Star) of Singapore [R143-000-391-305]
A click chemistry approach for the synthesis of small molecule inhibitor-peptide conjugates to achieve organelle-specific delivery has been developed. Biological testing showed that the inhibitor-Tat conjugate was successfully delivered to the lysosomes, leading to potent inhibition of lysosomal cysteine proteases in cultured cells.
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