期刊
CHEMICAL COMMUNICATIONS
卷 46, 期 30, 页码 5500-5502出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc00585a
关键词
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A straightforward, high-yielding, chemoenzymatic total synthesis of enantiopure (S)-Rivastigmine was developed using various omega-transaminases for the asymmetric amination of appropriate acetophenone precursors. Optimisation of the biotransformation allowed scale-up and the total synthesis of (S)-Rivastigmine.
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