4.7 Article

Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms

期刊

CHEMICAL COMMUNICATIONS
卷 46, 期 38, 页码 7220-7222

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02594a

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资金

  1. NSF [CHE-0748504]
  2. NIH [GM-093903]
  3. Johns Hopkins Malaria Research Institute
  4. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM093903] Funding Source: NIH RePORTER
  5. Division Of Chemistry [0748504] Funding Source: National Science Foundation

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In this communication, we reported another unique IspG-catalyzed transformation, the production of its substrate, MEcPP, from (2R,3R)-4-hydroxy-3-methyl-2,3-epoxybutanyl diphosphate (Epoxy-HMBPP) when reductants are excluded from the reaction mixture.

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