期刊
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY
卷 163, 期 -, 页码 29-38出版社
BLACKWELL PUBL LTD
DOI: 10.1111/1467-985X.00154
关键词
adaptive randomization; design of clinical trials; time-varying treatments
We propose a method for assigning treatment in clinical trials, called the 'biased coin adaptive within-subject' (BCAWS) design: during the course of follow-up, the subject's response to a treatment is used to influence the future treatment, through a 'biased coin' algorithm. This design results in treatment patterns that are closer to actual clinical practice and may be more acceptable to patients with chronic disease than the usual fixed trial regimens, which often suffer from drop-out and non-adherence. In this work, we show how to use the BCAWS design to compare treatment strategies, and we provide a simple example to illustrate the method.
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