期刊
CRITICAL CARE
卷 4, 期 2, 页码 91-100出版社
CURRENT SCIENCE LTD
DOI: 10.1186/cc662
关键词
acute lung injury; acute respiratory distress syndrome; compliance; lower inflection point; mechanical ventilation; method; positive end-expiratory pressure; pressure-volume curve; upper inflection point
Physiological background concerning mechanics of the respiratory system, techniques of measurement and clinical implications of pressure-volume curve measurement in mechanically ventilated patients are discussed in the present review. The significance of lower and upper inflection points, the assessment of positive end-expiratory pressure (PEEP)-induced alveolar recruitment and overdistension and rationale for optimizing ventilatory settings in patients with acute lung injury are presented. Evidence suggests that the continuous flow method is a simple and reliable technique for measuring pressure-volume curves at the bedside. In patients with acute respiratory failure, determination of lower and upper inflection points and measurement of respiratory compliance should become a part of the routine assessment of lung injury severity, allowing a bedside monitoring of the evolution of the lung disease and an optimization of mechanical ventilation.
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