期刊
CHEMICAL COMMUNICATIONS
卷 46, 期 31, 页码 5773-5774出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc00828a
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资金
- Wayne State University
- NSF [CHE-0554777]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM090270] Funding Source: NIH RePORTER
MUC1 glycopeptide was efficiently coupled to glycosylphosphatidylinositol (GPI) derivatives by sortase A (SrtA), verifying that SrtA can accept sterically hindered glycopeptide as substrate for ligation with GPIs. This work has established a practical method for the chemoenzymatic synthesis of GPI-linked glycopeptides.
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