Tandem Nazarov cyclization-halovinylation of divinyl ketones under Vilsmeier conditions: synthesis of highly substituted cyclopentadienes

A new Vilsmeier reagent-mediated Nazarov cyclization-halovinylation reaction of divinyl ketones was developed to provide a straightforward method for the synthesis of highly substituted cyclopentadienes with the advantages of simplicity of execution, readily available substrates, cheap reagents, and broad range of potential products and applications.