Highly regio- and stereoselective intermolecular tandem reaction to synthesize chloro-substituted 1,3-butadienes

A palladium catalyzed highly regio- and stereoselective intermolecular tandem reaction of alkynes, CuCl(2) and alkenes by a sequence of chloropalladation/Heck reaction to produce chloro-substituted 1,3-dienes is achieved.