Immobilization of calix[4]arene-based glycoclusters on TiO2 nanoparticles via click Cu(I)-catalyzed azide-alkyne coupling

We present the first type of tetraazide-functionalized calix[4]arene TiO2 nanoparticles and their coupling to propargyl glycosides under Cu(I)-catalysis (click reaction), resulting in the immobilization of calix[4]arene-based glycoclusters on the TiO2 surface.