期刊
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
卷 8, 期 1, 页码 5-10出版社
WESTMINSTER PUBL INC
DOI: 10.1177/106689690000800105
关键词
gastrointestinal stromal tumor; GIST; classification; histogenesis; pathogenesis; prognosis
Gastrointestinal stromal tumors (GISTs) have long been problematic in terms of classification and determination of prognosis. Recent studies have suggested that GISTs differentiate toward a phenotype resembling the interstitial cells of Cajal. This has led to the important discovery that activating mutations in the KIT receptor tyrosine kinase play an important role in the parhogenesis of GISTs. These findings have helped clarify the distinction between GISTs and other mesenchymal neoplasms of the gastrointestinal tract and may translate into an improved ability to predict biologic behavior, as well as suggesting possible avenues for rational drug design for the treatment of GISTs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据