期刊
JOURNAL OF ELASTICITY
卷 61, 期 1-3, 页码 165-197出版社
SPRINGER
DOI: 10.1023/A:1011082712497
关键词
development; morphogenesis; cardiac mechanics; finite elements; models
Mechanics plays a major role in heart development. This paper reviews some of the mechanical aspects involved in theoretical modeling of the embryonic heart as it transforms from a single tube into a four-chambered pump. In particular, large deformations and significant alterations in structure lead to highly nonlinear boundary value problems. First, the biological background for the problem is discussed. Next, a modified elasticity theory is presented that includes active contraction and growth, and the theory is incorporated into a finite element analysis. Finally, models for the heart are presented to illustrate the developmental processes of growth, remodeling, and morphogenesis. Combining such models with appropriate experiments should shed light on the complex mechanisms involved in cardiac development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据