Nickel(0)-catalyzed [2+2+2] cycloaddition of diynes and 3,4-pyridynes: novel synthesis of isoquinoline derivatives

A transition metal-catalyzed [2 + 2 + 2] cycloaddition between alpha,omega-diynes and 3,4-pyridynes has been realized for the first time, producing isoquinolines in good yields by using a nickel(0) catalyst.