期刊
CHEMICAL COMMUNICATIONS
卷 -, 期 47, 页码 7278-7287出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b917243m
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资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069445] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM069445, R01 GM069445-01A2, R01-GM69445] Funding Source: Medline
Existing methods for enantioselective carbonyl allylation, crotylation and tert-prenylation require stoichiometric generation of pre-metallated nucleophiles, and often employ stoichiometric chiral modifiers. Under the conditions of transfer hydrogenation employing an ortho-cyclometallated iridium C,O-benzoate catalyst, enantioselective carbonyl allylations, crotylations and tert-prenylations are achieved in the absence of stoichiometric metallic reagents or stoichiometric chiral modifiers. Moreover, under transfer hydrogenation conditions, primary alcohols function dually as hydrogen donors and aldehyde precursors, enabling enantioselective carbonyl addition directly from the alcohol oxidation level.
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