A facile method to clickable sensing polymeric nanoparticles

Clickable biocompatible nanoparticles were prepared in a one-pot process by microemulsion polymerization using acrylamide, N,N'-methylene bisacrylamide and either N-(11-azido-3,6,9-trioxaundecanyl) acrylamide or N-propargylacrylamide, which were then readily modified by CuAAC reaction to afford sensing nanomaterials.