4.7 Article

Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis

期刊

CHEMICAL COMMUNICATIONS
卷 -, 期 34, 页码 4040-4042

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/b810858g

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资金

  1. Swiss National Science Foundation [200020_119947]
  2. EPSRC [EP/D002818/1]
  3. AstraZeneca
  4. Swiss National Science Foundation (SNF) [200020_119947] Funding Source: Swiss National Science Foundation (SNF)
  5. Engineering and Physical Sciences Research Council [EP/D002818/1] Funding Source: researchfish

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The Pd-catalysed asymmetric intramolecular alpha-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used.

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