期刊
JOURNAL OF IMMUNOLOGY
卷 164, 期 5, 页码 2807-2814出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.164.5.2807
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资金
- NATIONAL CANCER INSTITUTE [K12CA076930, P01CA018029] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG000257] Funding Source: NIH RePORTER
- NCI NIH HHS [CA18029, CA76930] Funding Source: Medline
- NHGRI NIH HHS [HG00257] Funding Source: Medline
The mammalian Y chromosome encodes male-specific minor histocompatibility (H-Y) Ags that are recognized by female T cells in an MHC-restricted manner. Two human H-Y epitopes presented by HLA-A2 and HLA-B7, respectively, have been identified previously and both are derived from the SMCY gene. We previously isolated CD8(+) CTL clones that recognized a male-specific minor histocompatibility Ag presented by HLA-BS. In contrast to the SMCY encoded H-Y epitopes, the B8/H-Y Ag was not presented by fibroblasts from male donors, suggesting that it was encoded by a novel gene. We now report that the HLA-B8-restricted H-Y epitope is defined by the octameric peptide LPHNHTDL corresponding to aa residues 566-573 of the human UTY protein. Transcription of the UTY gene is detected in a wide range of human tissues, but presentation of the UTY-derived H-Y epitope to CTL by cultured human cells shows significant cell-type specificity. Identification of this CTL-defined H-Y epitope should facilitate analysis of its contribution to graft/host interactions following sex-mismatched organ and bone marrow transplantation.
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