期刊
CHEMICAL COMMUNICATIONS
卷 -, 期 39, 页码 4768-4770出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b809099h
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资金
- University of Massachusetts
- American Cancer Society [IRG 93-033]
- NIH [GM077413]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM077413] Funding Source: NIH RePORTER
HIF-asparaginyl hydroxylase (FIH-1) normally couples O(2)-activation to hydroxylation of Asn(803) on the alpha-subunit of the hypoxia-inducible factor (HIF alpha), a key step in pO(2) sensing; in the absence of HIF alpha, O(2)-activation becomes uncoupled, leading to self-hydroxylation at Trp(296) and a purple Fe(III)-O-Trp chromophore-this alternative reactivity may affect human hypoxia sensing.
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