4.7 Article

Substrate mediated reduction of copper-amyloid-beta complex in Alzheimer's disease

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CHEMICAL COMMUNICATIONS
卷 -, 期 27, 页码 3169-3171

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ROYAL SOC CHEMISTRY
DOI: 10.1039/b803911a

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  1. US Department of Energy, Office of Basic Energy Sciences [DE-AC02-06CH11357]
  2. Commonwealth of Australia

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X-Ray absorption near-edge spectroscopy (XANES) has been used to probe the substrate mediated reduction of Cu2+ in A beta-Cu2+ complexes by ascorbate and the neurotoxin 6-hydroxydopamine (6-OHDA), however dopamine and, in particular, cholesterol are incapable of reducing soluble monomeric A beta-Cu2+ complexes.

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