期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 106, 期 3, 页码 429-440出版社
MOSBY-ELSEVIER
DOI: 10.1067/mai.2000.109428
关键词
mast cell; Fc epsilon RI; Fc gamma RIIB; inhibitory receptors; signal transduction
Immune responses are tightly controlled by the activities of both activating and inhibitory signals. At the cellular level, these signals are generated through engagement of membrane-associated receptors and coreceptors. The high-affinity IgE receptor Fc epsilon RI is expressed on mast cells and basophils and, on cross-linking by multivalent antigen (allergen), stimulates the release of inflammatory mediators that induce acute allergic responses. Activation signals mediated by a variety of immune receptors (eg, B-cell receptor, T-cell receptor, and Fc epsilon RI) are subject to negative regulation by a growing family of structurally and functionally related inhibitory receptors, Recent studies indicate that mast cells express multiple inhibitory receptors that may regulate Fc epsilon RI-induced mast cell activation through similar mechanisms. The ability of inhibitory receptors to attenuate IgE-mediated allergic responses implicates them as potential targets for therapeutic intervention in the treatment of atopic disease. Indeed, coaggregation of activating and inhibitory receptors has been suggested as one possible mechanism to explain the beneficial effects of specific immunotherapy in the treatment of allergy. In this review we summarize the current knowledge of inhibitory receptors expressed in mast cells and the mechanisms through which they regulate mast cell function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据