期刊
JOURNAL OF BACTERIOLOGY
卷 182, 期 17, 页码 5025-5028出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.182.17.5025-5028.2000
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- NCI NIH HHS [R01-CA77193] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA077193] Funding Source: NIH RePORTER
Overexpression of the MutS repair protein significantly decreased the rate of lacZ GC --> TA transversion mutation in stationary-phase and exponentially growing bacteria and in mutY and mutM mutants, which accumulate mismatches between 8-oxoguanine (8-oxoG) and adenine residues in DNA. Conversely, GC --> TA transversion increased in mutL or mutS mutants in stationary phase. In contrast, overexpression of MutS did not appreciably reduce lacZ AT --> CG transversion mutation in a mutT mutant. These results suggest that MutS-dependent repair can correct 8-oxoG:A mismatches in Escherichia coli cells but may not be able to compete with mutation fixation by MutY in mutT mutants.
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