期刊
BRAIN RESEARCH
卷 875, 期 1-2, 页码 51-55出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)02597-X
关键词
amino acid; cell swelling; controlled cortical impact injury; excitotoxicity; high-performance liquid chromatography; volume-regulation
Glutamate-mediated excitotoxicity results in cell swelling and contributes to brain edema formation. Since increased extracellular taurine reflects glutamate-induced cell swelling in vitro, elevated CSF taurine could therefore unmask glutamate-mediated cytotoxic edema formation under in vivo conditions. For this, the temporal profile of brain edema and changes in cisternal CSF glutamate and taurine levels were determined in 28 rats following focal traumatic brain injury. Compared to six non-traumatized rats, CSF glutamate (4.8+/-0.3 vs. 10+/-0.9 mu M) and taurine levels (12+/-1.3 vs. 41+/-3 mu M) were significantly increased at 8 h after trauma (P<0.001). Over time, CSF glutamate and taurine were significantly increased by 24 (glutamate: 38+/-4.4 mu M) and 48 h (taurine: 51+/-4 mu M), respectively. While CSF glutamate closely reflected changes in hemispheric water content, alterations in CSF taurine occurred diametrically to those seen for glutamate. Under the present study design, increased CSF taurine could reflect glutamate-induced cell swelling. In addition, neuronal release of taurine with its inhibitory and antiexcitotoxic functions could explain the observed diametric changes in CSF glutamate, CSF taurine, and hemispheric water content. Therefore, increasing taurine could be a therapeutic approach in attenuating post-traumatic glutamate-mediated cell damage. (C) 2000 Elsevier Science B,V. All rights reserved.
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