期刊
STROKE
卷 31, 期 3, 页码 645-650出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.STR.31.3.645
关键词
cardiac surgery; follow-up studies; nerve tissue protein S-100; neuron-specific enolase; neuropsychology
Background and Purpose-The goal of the present study was to;investigate the predictive value of neurobiochemical markers of brain damage (protein S-100B and neuron-specific;enolase [NSE]) with respect to the short- and long-term neuropsychological outcomes after cardiac surgery with cardiopulmonary bypass (CPB). Methods-We investigated 74 patients who underwent elective CABG or Valve replacement surgery and who showed no severe neurological deficits after surgery. Patients were investigated;with a standardized neurological examination and a comprehensive neuropsychological and neuropsychiatric assessment 1 to 2 days before surgery, 3 and 8 days after surgery, and 6 months later. Serial venous blood samples were taken preoperatively and 1, 6, 20, and 30 hours after skin closure. Protein S-100B and NSE were analyzed with immunoluminometric assays. Results-Patients with severe postoperative neuropsychological disorders showed a significantly higher and longer release of neurobiochemical markers of brain damage. Patients who presented with a delirium according to DSM-III-R criteria 3 days after surgery had significantly higher postoperative S-100B serum concentrations. Multivariate analysis (based on postoperative NSE and S-100B concentrations and age of:patients, type of operation, length of cross-clamp and perfusion time, and intraoperative and postoperative oxygenation) identified NSE and S-100B concentrations 6 to 30 hours after skin closure as the only variables that contributed significantly to a predictive model of the neuropsychological outcome. NSE, but not S-100B, release was significantly higher in patients undergoing valve replacement surgery. Conclusions-Postoperative serum concentrations and kinetics of S-100B:and NSE have a high predictive value with respect to the early neuropsychological and neuropsychiatric outcome after cardiac surgery. The analysis of NSE and S-100B release might allow insight into the underlying pathophysiology of brain dysfunction, thus providing a valuable tool to monitor and evaluate measures to improve cardiac surgery with CPB.
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