期刊
INFECTION AND IMMUNITY
卷 68, 期 3, 页码 1080-1085出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.3.1080-1085.2000
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资金
- NATIONAL EYE INSTITUTE [R01EY007757] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI024436, R01AI032943] Funding Source: NIH RePORTER
- NEI NIH HHS [EY07757] Funding Source: Medline
- NIAID NIH HHS [AI24436, R01 AI032943, AI32943] Funding Source: Medline
Using polystyrene microspheres coated with heparin or heparan sulfate, it was shown that coated microspheres specifically bound eukaryotic cells and were endocytosed by nonprofessional phagocytic cells. Coated microspheres displayed properties of binding to eukaryotic cells that were similar to those of chlamydiae, and the microspheres were competitively inhibited by chlamydial organisms, Endocytosis of heparin-coded beads resulted in the tyrosine phosphorylation of a similar set of host proteins as did endocytosis of chlamydiae; however, unlike viable chlamydial organisms, which prevent phagolysosomal fusion, endocytosed beads were trafficked to a lysosomal compartment, These findings suggest that heparin-coated beads and Chlamydia trachomatis enter eukaryotic cells by similar pathways.
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