期刊
JOURNAL OF BACTERIOLOGY
卷 182, 期 1, 页码 236-240出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.182.1.236-240.2000
关键词
-
类别
资金
- NIAID NIH HHS [F31 AI09638, F31 AI009638] Funding Source: Medline
- NIGMS NIH HHS [GM47296, R01 GM047296] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [F31AI009638] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM047296] Funding Source: NIH RePORTER
Work presented here establishes a connection between cellular coenzyme A (CoA) levels and thiamine biosynthesis in Salmonella enterica serovar Typhimurium. Prior work showed that panE mutants (panE encodes ketopantoate reductase) had a conditional requirement for thiamine or pantothenate. Data presented herein show that the nutritional requirement of panE mutants for either thiamine or pantothenate is manifest only when flux through the purine biosynthetic pathway is reduced. Further, the data show that under the above conditions it is the lack of thiamine pyrophosphate, and not decreased CoA levels, that directly prevents growth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据