期刊
CHEMICAL COMMUNICATIONS
卷 -, 期 32, 页码 3786-3788出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b802248h
关键词
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The chemoenzymatic installation of the clinically valuable (S)-4-amino-2-hydroxybutyryl side chain onto a number of 2-deoxystreptamine-containing aminoglycosides is described using the purified Bacillus circulans biosynthetic enzymes BtrH and BtrG in combination with a synthetic acyl-SNAC surrogate substrate.
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