期刊
JOURNAL OF VIROLOGY
卷 74, 期 2, 页码 1029-1032出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.2.1029-1032.2000
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Control of ganglionic herpes simplex virus (HSV) infection depends on CD8(+) cells but not on the death of infected neurons. Primarily, perforin and granzyme B mediate CD8(+) cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown, Here, it is shown that granzyme A restricts the interneuronal spread of HSV and significantly influences ganglionic virus load.
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