期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 85, 期 6, 页码 729-742出版社
WILEY
DOI: 10.1111/cbdd.12457
关键词
arachidonic acid; chalcones; Claisen-Schmidt condensation; flavonoids; lipopolysaccharides
资金
- Research Incentive Fund of Universiti Kebangsaan Malaysia [UKM-DLP-2013-013]
A novel series of 1,3-diphenyl-2-propen-1-one (chalcone) derivatives was synthesized by a simple, eco-friendly, and efficient Claisen-Schmidt condensation reaction and used as precursors for the synthesis of new pyrazoline derivatives. All the synthesized compounds were screened for anti-inflammatory related activities such as inhibition of phospholipase A(2) (PLA(2)), cyclooxygenases (COX-1 and COX-2), IL-6, and TNF-. The results of the above studies show that the compounds synthesized are effective inhibitors of above pro-inflammatory enzymes and cytokines. Overall, the results of the studies reveal that the pyrazolines with chlorophenyl substitution (1b-6b) seem to be important for inhibition of enzymes and cytokines. Molecular docking experiments were performed to clarify the molecular aspects of the observed COX-inhibitory activities of the investigated compounds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据