Chiral amine-silyl triflate complex mediated asymmetric intramolecular Michael-aldol reaction via a novel enantioselective enol silylation process

An asymmetric intramolecular Michael-aldol reaction of a C-s symmetric ketone using chiral amine and silyl triflate is described as a new methodology of chiral induction; nonracemic tricyclic cyclobutanes were obtained from a 4-substituted cyclohexanone in high yields with moderate enantioselectivities in one step.