期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 84, 期 5, 页码 578-584出版社
WILEY
DOI: 10.1111/cbdd.12348
关键词
asparagine synthetase; breast cancer; cell proliferation; RNA interference
资金
- Natural Science Foundation of Zhejiang Province, China [LY12H16030]
- Foundation of Science Technology Department of Zhejiang Province, China [2011C23043]
- Foundation of Health Department of Zhejiang Province, China [2011BCA015]
- Traditional Chinese Medical Research Foundation of Zhejiang Province, China [2011ZA016]
Asparagine synthetase (ASNS) is deemed to be a promising therapeutic target for the treatment of several cancers, but its functional role in human breast cancer is still unknown. In this study, we employed RNA interference as an efficient tool to silence endogenous ASNS expression in breast cancer cell lines. The relationship between ASNS expression and breast cancer cell growth was investigated, and the therapeutic value of ASNS in breast cancer was further evaluated. Depletion of ASNS remarkably inhibited the proliferation and colony formation capacity of breast cancer cells and arrested cell cycle in the S phase. Our findings suggest that ASNS may contribute to breast cancer tumorigenesis and could be a potential therapeutic target in human breast cancer.
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