期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 82, 期 6, 页码 732-742出版社
WILEY
DOI: 10.1111/cbdd.12184
关键词
apoptosis; chalcones; chromatin condensation; cytotoxicity; DNA damage; flow cytometry
资金
- VIT University, Vellore
- Manipal university, Manipal
Methoxy-substituted chalcones, 3 were obtained using simple, efficient method from 2-naphtylethanone, 1 and aromatic aldehydes, 2. The in vitro cytotoxicity activities of the chalcones against a panel of three human cancer cell lines were explored. The tested compounds were found to possess significant cytotoxic activity. The DNA strand break and damage was quantified through alkaline comet assay, flow cytometric analysis, and chromatin condensation studies, which revealed the apoptotic nature of the compounds. Compound 3c, (3-(3,4,5-trimethoxyphenyl)-1-(2-naphthyl) prop-2-en-1-one) showed highest cytotoxicity of 0.019m against HeLa, 0.020m against HCT15 and 0.022m against A549. Compound 3e, (3-(3,5-dimethoxyphenyl)-1-(2-naphthyl) prop-2-en-1-one) showed better IC50 values against all the three cell lines employed for the study.
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