期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 81, 期 1, 页码 102-112出版社
WILEY
DOI: 10.1111/cbdd.12057
关键词
cancer; mitochondria; mitochondrial DNA; retrograde pathway; yeast
资金
- Italian Ministry of Economy and Finance
- MIUR Merit [RBNE08HWLZ_012, RBNE08YFN3_005, PRIN 2009R8LJPS_002]
- Fondazione Cassa di Risparmio di Puglia
In addition to their role as cell powerhouse mitochondria are key organelles in the processes deciding about cell life or death that are crucial for tumor cell growth and survival, as well as for tumor cell ability to metastasize. Alterations in mitochondrial structure and functions have long been observed in cancer cells, thus targeting mitochondria as an anticancer therapeutic strategy has gained momentum recently. We will review the achievements and perspectives in the elucidation of the molecular basis for developing mitochondrial-targeted compounds as potential anticancer agents with special attention to mitochondrial DNA mutations and mitochondrial dysfunction. Molecules/agents candidate to affect mitochondrial metabolism in cancer cells will be dealt with, with a particular focus on approaches targeting defects in the mitochondrial genome.
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