期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 81, 期 1, 页码 148-165出版社
WILEY-BLACKWELL
DOI: 10.1111/cbdd.12042
关键词
aza-amino acid; conformational constraint; Freidinger lactam; peptidomimetic; scan; stapled peptide
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Institutes of Health Research (CIHR) [TGC-114046]
- University of Leicester
Peptide-based therapeutics have grown in importance over the last few decades. Furthermore, peptides have been extensively used as lead compounds in the drug discovery process to investigate the nature of chemical space required for molecular recognition and activity at a variety of targets. This critical commentary reviews scanning techniques, which employ natural and non-proteinogenic amino acids to facilitate understanding of structural requirements for peptide biological activity. The value of sequence analysis by such methods is highlighted by examples, in which the elements for peptide affinity and activity have been elucidated and employed to prepare peptidomimetic leads for drug development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据