期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 75, 期 4, 页码 339-347出版社
WILEY
DOI: 10.1111/j.1747-0285.2010.00946.x
关键词
drug discovery; drug lead; riboflavin synthesis; riboswitch
资金
- National key infectious disease project [2008ZX10003-006]
- National natural science foundation [90813019]
- National S&T platform project [2005DKA2120610]
- Southwest University Graduate Innovation Fund [ky2009009]
Riboflavin (vitamin B-2) is the direct precursor of redox enzyme cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential for multiple cell physiology. The riboflavin biosynthetic pathway is regarded as a rich resource for therapeutic targets for broad spectrum antibiotics. Enzymatic pathways, regulatory factors of the riboflavin biosynthesis, and relevant drug discovery are summarized in this review. The novel riboswitch regulatory mechanism of riboflavin metabolism is also described. A compendium of chemical modulators of riboflavin biosynthesis and regulatory networks is listed and such demonstrates the promise of riboflavin biosynthesis and regulatory mechanisms as potential therapeutic targets for novel antibiotic drug discovery.
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