期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 75, 期 3, 页码 277-283出版社
WILEY
DOI: 10.1111/j.1747-0285.2009.00942.x
关键词
2-aminopyrrole; aminoacetophenone sulfonamides; cyanoacetamides; multicomponent reaction
资金
- National Institute of Health [GM087617]
The design of an unprecedented multicomponent reaction to and synthesis of 2-amino-5-ketoaryl pyrroles are described. The compounds (14 examples) can be synthesized by reacting aminoacetophenone sulfonamides, (hetero)aromatic aldehydes, and malonodinitrile or cyanoacetic acid derivatives in one-pot manner. Pharmacophore features and potential applications of this new scaffold are discussed.
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