期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 75, 期 4, 页码 375-380出版社
WILEY
DOI: 10.1111/j.1747-0285.2009.00937.x
关键词
Biginelli reaction; cytotoxicity; dihyropyrimidinone; microwave irradiation; multicomponent; terephthalic aldehyde; TMSCl
资金
- Islamic Azad University-South Tehran
- research council of Shiraz University of Medical Sciences
An effective one-pot synthesis of bis(dihydropyrimidinonoe)benzenes using chlorotrimethylsilane (TMSCl) through Biginelli condensation reaction of terephthalic aldehyde, 1,3-dicarbonyl compounds and (thio)urea or guanidine under microwave irradiation conditions is described. Excellent yields of the products and simple work-up are attractive features of this green protocol. Then, the cytotoxic activities of these compounds were evaluated on five different human cancerous cell lines (Raji, HeLa, LS-180, SKOV-3 and MCF7). Their cytotoxic study indicated that they possessed a weak to moderate activity. Furthermore, the higher activity of compound 4b bearing sulfur in C-2 position of pyrimidinone ring showed the importance of this site for cytotoxic activity of these compounds.
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