期刊
JOURNAL OF CLINICAL ONCOLOGY
卷 18, 期 6, 页码 1331-1336出版社
AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/JCO.2000.18.6.1331
关键词
-
类别
Purpose: To report our experience with both I-123-vasoactive intestinal peptide (VIP) and In-111-DTPA-D-phe(1)-octreotide for imaging to identify primary and metastatic tumor sites in carcinoid patients. Patients and Methods: One hundred ninety-four patients with a verified or clinically suspected diagnosis of a carcinoid tumor were injected with In-111-DTPA-D-Phe(1)-OCT for imaging purposes, while 133 patients underwent scanning with both I-123-VIP and In-111-DTPA-D-phe(1)-OCT in random order. Imaging results were compared with computed tomagraphy scans, results of conventional ultrasound, endosonography, and endoscopy, and results of surgical exploration in case of inconclusive conventional imaging. Results: Primary or recurrent carcinoid tumors could be visualized with In-111-DTPA-D-Phe(1)-OCT in 95 (91%) of 104 patients; metastatic sites were identified in 110 (95%) of 116 patients. In 11 (51%) of 21 patients with suggestive symptoms but without identified lesions by conventional imaging, focal tracer uptake located the carcinoid tumor. In addition, metastatic disease war demonstrated in three patients after resection. in a direct comparison in the 133 patients who underwent both imaging modalities, In-111-DTPA-D-Phe(1)-OCT was found to be superior to I-123-VIP, with 35 (93%) of 38 versus 32 (82%) of 38 scans being positive in primary or recurrent tumors, 58 (90%) of 65 versus 53 (82%) of 65 being positive in patients with metastatic sites, and seven (44%) of 16 versus four (25%) of 16 being positive in patients with symptoms but otherwise negative work-ups. Overall, additional lesions not seen on conventional imaging were imaged in 43 (41%) of 158 versus 25 (25%) of 103 scans with In-111-DTPA-D-Phe(1)-OCT and I-123-VIP, respectively. Conclusion: Both peptide tracers have a high sensitivity for localising tumor sites in patients with ascertained or suspected carcinoid tumors, with In-111-DTPA-D-phe(1)-OCT scintigraphy being more sensitive than I-123-VIP receptor scanning. Both, however, had a higher diagnostic yield than conventional imaging, as verified by surgical intervention or long-term followup. The combination of both peptide receptor scans does not seem to further enhance diagnostic information, (C) 2000 by American Society of Clinical Oncology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据