期刊
EMBO JOURNAL
卷 19, 期 5, 页码 882-891出版社
OXFORD UNIV PRESS
DOI: 10.1093/emboj/19.5.882
关键词
endosomes; invariant chain; MHC class II
资金
- NATIONAL CANCER INSTITUTE [P30CA014051] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI034893] Funding Source: NIH RePORTER
- NCI NIH HHS [2-P30-CA14051, P30 CA014051] Funding Source: Medline
- NIAID NIH HHS [5-RO1-AI34893, R01 AI034893] Funding Source: Medline
Major histocompatibility complex (PI;IHC) class II molecules bind and present to CD4(+) T cells peptides derived from endocytosed antigens. Class II molecules associate in the endoplasmic reticulum with invariant chain (Ii), which (i) mediates the delivery of the class II-Ii complexes into the endocytic compartments where the antigenic peptides are generated; and (ii) blocks the peptide-binding site of the class II molecules until they reach their destination. Once there, Ii must be removed to allow peptide binding. The bulk of Ii-class II complexes reach late endocytic compartments where Ii is eliminated in a reaction in which the cysteine protease cathepsin S and the accessory molecule H-2DM play an essential role. Here, we here show that Ii is also eliminated in early endosomal compartments without the intervention of cysteine proteases or H-2DR I. The Ii-free class II molecules generated by this alternative mechanism first bind high molecular weight polypeptides and then mature into peptide-loaded complexes.
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