期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 72, 期 3, 页码 182-188出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1747-0285.2008.00689.x
关键词
Fmoc strategy; microwave irradiation; N-Fmoc-protected(alpha-dipeptidoyl)benzotriazoles; segment condensation; solid-phase peptide synthesis
N-Fmoc-protected(alpha-aminoacyl)benzotriazoles 1a-d readily afford chiral N-Fmoc-protected-alpha-dipeptides 2a-f (77-89%). Compounds 2a-f are further converted into N-Fmoc-protected(alpha-dipeptidoyl)benzotriazoles 3a-f (71% average yield). Under mild microwave irradiation, 3a-f are used in solid-phase peptide segment condensation syntheses to give tri-, tetra-, penta-, hexa-, and heptapeptides (20-68%).
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